What We Do At EDS
Genes And Their Role In Cancer
Each gene codes a specific protein which in turn perform various functions. Humans code over 20 thousand genes so that our bodies can perform its many functions. Muscles to move, blood cells to transport oxygen and insulin to process glucose to name just a few. Over the years, the genetic science community has determined the gene blueprint contained on specific DNA strands and the function of thousands of these genes.
Other researchers are hard at work performing epidemiological studies to determine healthy and un-healthy interactions including foods, behaviors and chemical interactions. These studies produce valuable data that help guide our life choices. Exercise is good for you, smoking is bad, apples and broccoli are good, etc…
Once epidemiological studies produce data, other researchers consider the mechanism of action of the health/unhealthy interactions. They try to answer why is broccoli healthy? What are the biological changes produced by consuming it? And finally, once the specific chemicals in broccoli are isolated and tested, they determine which genes are effected.
We read these headlines and try to live a healthy life. But internally, everything we consume and every chemical we encounter move genes in a mostly random fashion. Picture a toddler playing a piano with 20,000 keys. Each key representing a gene. The random noise produced is our genes being promoted or inhibited by what we interact with daily. We hope for the best and through our life choices try to hit more high notes than low.
When disease hits, our bodies are moving enough genes in the wrong direction to negatively affect our health. Further, genetic mutations accumulate over time so the proteins they code do not function as expected. Cancer is one disease that has been firmly associated with genetic mutation. There’s no doubt mutations are one driver of cancer. Additionally, many cancer promoting genes (oncogenes) have been identified. Together, these genes present targets for treatment. The majority of cancer medications target these specific genes. Existing cancer drugs target one or two genes and hit them hard. They keep banging on one or two keys of the 20,000-gene piano.
Epigenetics is the study of gene expression. How and why certain genes are expressed (produce a protein) and others are silenced. There is a substantial and growing body of research that is looking at epigenetic dysregulation as a major contributor to cancer. In fact, epigenetic features are more common in cancer than mutations.
This begs the question. What if we could manipulate the gene expression of cancer patients to produce a more normal pattern of protein generation? What if we could reduce the gene expression of onco-genes (cancer causing genes) and enhance the expression of tumor suppressor proteins. What if we could put a trained musician at the piano to hit just the notes we want. Instead of random noise, we could try to produce a well-orchestrated symphony of music.
What We Do
Epigenetic Data Sciences was founded with the mission to pull the existing data from hundreds of thousands of research papers that are sitting in islands of databases throughout the world to determine, scientifically, what is the best combination of chemicals (foods/supplements/herbs) to push back against cancer’s dysregulation of genes at every point. Instead of targeting just one or two keys genes, EDS is using a 360° approach to target over one hundred and fifty effected genes. Using sophisticated software and database technology, EDS tests billions of combinations to formulate optimized plans that take the guesswork out of answering the question "What can I do to help in my fight?" for breast cancer patients.